P300 Event-Related Potentials in Epileptic Children
| Autor: | Takayuki Otsuka, Akio Hikima, Kanji Nagashima, Yasuo Sunaga, Takayoshi Kuroume |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Thalamus Audiology Reticular formation Temporal lobe Pitch Discrimination Idiopathic generalized epilepsy 03 medical and health sciences Epilepsy 0302 clinical medicine Event-related potential 030225 pediatrics Reaction Time medicine Humans Attention Latency (engineering) Generalized epilepsy Child Cerebral Cortex medicine.disease Epilepsy Temporal Lobe Child Preschool Evoked Potentials Auditory Anticonvulsants Drug Therapy Combination Epilepsy Generalized Female Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Clinical Electroencephalography. 25:13-17 |
| ISSN: | 0009-9155 |
| DOI: | 10.1177/155005949402500106 |
| Popis: | To evaluate the cognitive function of epileptic children, we examined P300 in 50 patients, 32 with idiopathic generalized epilepsy (IGE) and 18 with temporal lobe epilepsy (TLE), and 39 normal children. There were significant negative correlations between age and P300 latencies at Pz and Cz in normal controls. For data analysis, we used the age-corrected latency, which was calculated as the interval between the actual and predicted P300 latencies. The predicted latency was calculated with the regression equation as the relationship between P300 latency and age in normal controls. The age-corrected P300 latencies recorded from Pz and Cz were significantly longer in patients with IGE (41.5 +/- 13.1, 42.0 +/- 12.5) than in control subjects (0 +/- 7.5, 0 +/- 7.9). There were no significant differences in age-corrected P300 latencies between patients with TLE (21.2 +/- 17.6, 31.5 +/- 17.0) and controls, or IGE and TLE. Recently, it was considered that the mesencephalic reticular formation and thalamus may play major roles in the genesis of generalized epilepsy, so we speculate that dysfunction of these systems may contribute to the prolongation of P300 in children with idiopathic generalized epilepsy. |
| Databáze: | OpenAIRE |
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