Early out-of-hospital lidocaine administration decreases the incidence of primary ventricular fibrillation in acute myocardial infarction
| Autor: | Laura Russo, Tamara Taddei, Bertini G, Alberto Conti, Cristina Giglioli, Carlo Rostagno, Barbara Paladini |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Emergency Medical Services Time Factors Lidocaine Myocardial Infarction Placebo Sudden death Bolus (medicine) medicine Humans Hospital Mortality Prospective Studies cardiovascular diseases Myocardial infarction Infusions Intravenous Aged business.industry Incidence Coronary Care Units Middle Aged medicine.disease Primary ventricular fibrillation Anesthesia Injections Intravenous Ventricular Fibrillation Ventricular fibrillation Emergency Medicine Coronary care unit Female business Mobile Health Units medicine.drug |
| Zdroj: | The Journal of Emergency Medicine. 11:667-672 |
| ISSN: | 0736-4679 |
| DOI: | 10.1016/0736-4679(93)90624-g |
| Popis: | This study was designed to assess the effectiveness of early prehospital intravenous administration of lidocaine in preventing primary ventricular fibrillation (PVF) in patients with suspected acute myocardial infarction (AMI). Sixty patients with suspected AMI, seen by the Mobile Coronary Care Unit (MCCU) of Florence, were randomly allocated at home to treatment with lidocaine (bolus i.v. of 1 mg/kg, followed by an infusion of 4 mg/min) or placebo (infusion of saline at a rate of 1 mL/min), respectively. The lidocaine group (27 patients) and the control group (33 patients) were not significantly different in age, clinical condition, or time of randomization. The diagnosis of AMI was confirmed in all 60 patients during the hospital stay. Ventricular fibrillation (VF) occurred in 5 patients in the control group in comparison to none in the lidocaine group (P0.05). Three patients experienced VF at home and were successfully resuscitated by an MCCU cardiologist. In another two patients, VF occurred during the first 4 hours after onset of symptoms. No major side effects were observed after the infusion of lidocaine. Our findings support the effectiveness of the prophylactic administration of lidocaine in preventing PVF in the prehospital phase of AMI and suggest that the drug can be safely administered in this setting by prehospital personnel. |
| Databáze: | OpenAIRE |
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