Axonal chronic injury in treatment-naïve HIV+ adults with asymptomatic neurocognitive impairment and its relationship with clinical variables and cognitive status
| Autor: | Ruili Li, Jun Sun, Zhenchao Tang, Jing-ji Zhang, Hongjun Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Pathology medicine.medical_specialty External capsule Internal capsule HIV Infections Corpus callosum lcsh:RC346-429 White matter 03 medical and health sciences 0302 clinical medicine Corona radiata Fractional anisotropy medicine Humans Cognitive Dysfunction lcsh:Neurology. Diseases of the nervous system business.industry HIV Asymptomatic neurocognitive impairment General Medicine Axons 030104 developmental biology medicine.anatomical_structure Diffusion tensor imaging nervous system Neurology (clinical) business Neurocognitive 030217 neurology & neurosurgery Diffusion MRI Research Article |
| Zdroj: | BMC Neurology BMC Neurology, Vol 18, Iss 1, Pp 1-12 (2018) |
| ISSN: | 1471-2377 |
| Popis: | Background HIV is a neurotropic virus, and it can bring about neurodegeneration and may even result in cognitive impairments. The precise mechanism of HIV-associated white matter (WM) injury is unknown. The effects of multiple clinical contributors on WM impairments and the relationship between the WM alterations and cognitive performance merit further investigation. Methods Diffusion tensor imaging (DTI) was performed in 20 antiretroviral-naïve HIV-positive asymptomatic neurocognitive impairment (ANI) adults and 20 healthy volunteers. Whole-brain analysis of DTI metrics between groups was conducted by employing tract-based spatial statistics (TBSS), including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). DTI parameters were correlated with clinical variables (age, CD4+ cell count, CD4+/CD8+ ratio, plasma viral load and duration of HIV infection) and multiple cognitive tests by using multilinear regression analyses. Results DTI quantified diffusion alterations in the corpus callosum and corona radiata (MD increased significantly, P |
| Databáze: | OpenAIRE |
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