Amphetamine effects on startle gating in normal women and female rats
| Autor: | Neal R. Swerdlow, Jo Talledo, Ashley N. Sutherland Owens, Tijmen Schortinghuis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Reflex Startle Dopamine Strains Pharmacology Nucleus accumbens Sensorimotor gating Article Nucleus Accumbens Rats Sprague-Dawley chemistry.chemical_compound Basal (phylogenetics) Double-Blind Method Species Specificity Internal medicine medicine Animals Humans Rats Long-Evans Amphetamine Neurotransmitter Pharmacology/Toxicology Prepulse inhibition Psychiatry Cross-Over Studies Dose-Response Relationship Drug Dopaminergic Neurosciences Startle Rats Biomedicine Endocrinology chemistry Dopamine Agonists Catecholamine Central Nervous System Stimulants Female Psychology Psychomotor Performance medicine.drug |
| Zdroj: | Talledo, Jo A.; Sutherland Owens, Ashley N.; Schortinghuis, Tijmen; & Swerdlow, Neal R.(2009). Amphetamine effects on startle gating in normal women and female rats. Psychopharmacology, 204(1), pp 165-175. doi: 10.1007/s00213-008-1446-7. Retrieved from: http://www.escholarship.org/uc/item/92c387s7 |
| DOI: | 10.1007/s00213-008-1446-7. |
| Popis: | Dopamine agonists disrupt prepulse inhibition (PPI) of startle in male rodents. In humans, this is observed only in some studies. We reported that PPI was disrupted by d-amphetamine in men, but only among those with high basal PPI levels. Here, amphetamine effects on PPI were tested in normal women and female rats. Acoustic startle and PPI were tested in normal women after placebo or 20 mg amphetamine, in a double-blind, crossover design, and in female rats after vehicle or 4.5 mg/kg amphetamine. Rats were from Sprague–Dawley (SD) and Long Evans (LE) strains that differ significantly in gene expression in PPI-regulatory circuitry, including levels of nucleus accumbens (NAC) catechol-O-methyl transferase (COMT) mRNA. Amphetamine was bioactive in humans based on quantitative autonomic and self-rating measures, but did not significantly change startle magnitude or PPI across all subjects. Amphetamine’s effects on PPI in women correlated significantly (p |
| Databáze: | OpenAIRE |
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