Zinc-Mediated Stereoselective Barbier Allylation of N-Carbethoxy-α-Amino Ketones in Aqueous Solution

Autor:	Lucia C. S. Aguiar, O. A. C. Antunes, Gabriel O. de Resende
Rok vydání:	2005
Předmět:	Barbier reaction Phenylketones Allylic rearrangement Aqueous solution Chemistry Organic Chemistry chemistry.chemical_element Organic chemistry Stereoselectivity General Medicine Zinc Medicinal chemistry Vicinal
Zdroj:	ChemInform. 36
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200522029
Popis:	Zinc-mediated aqueous allylic Barbier reaction of N-carbethoxy-α-amino phenylketones was carried out with good diastereoselectivity (up to 95% de), leading to vicinal amino alcohols. The corresponding reaction using N-carbethoxy-α-amino methyl-ketones did not present good facial diastereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e359a5100c5fbdf452c9fb863f6754 https://doi.org/10.1002/chin.200522029 Zobrazit plný text záznamu Plný text