Improvement instead of stability in embryo quality between day 3-5: A possible extra predictor for blastocyst selection
| Autor: | M. van Rumste, Kelly Tilleman, Ilse DeCroo, Benedictus C. Schoot, P. De Sutter, C. Blank, B. Weyers, Massimo Mischi, L. van Avermaet |
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| Rok vydání: | 2020 |
| Předmět: |
Pregnancy Rate
medicine.medical_treatment Single Embryo Transfer Fertilization in Vitro Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy Medicine Humans 030212 general & internal medicine Blastocyst Embryo Implantation Retrospective Studies 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Blastocyst Transfer Obstetrics and Gynecology Embryo medicine.disease Embryo Transfer medicine.anatomical_structure Reproductive Medicine embryonic structures Female business Live birth Embryo quality |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 253 |
| ISSN: | 1872-7654 |
| Popis: | Objective The aim of this study was to evaluate the predictive value of the dynamic morphological development process between cleavage-stage and blastocyst-stage embryos. Study design A retrospective study was executed between 2015 and 2017 at Ghent University Hospital. A total of 996 first fresh IVF/ICSI cycles resulting in a single embryo transfer on day 5 were included. Embryos were scored on day 3 and day 5 as excellent, good, moderate or poor based on Alpha/ESHRE guidelines and Gardner and Schoolcraft scoring-system. If embryos changed category between day 3 and 5, the number of steps (between excellent; good; moderate; poor) in positive and negative direction was expressed. Results On day 5, the ongoing pregnancy rate (OPR) of excellent embryos was 37.4 %. Univariate analyses showed that on day 5, both a higher cell stage, better inner cell mass and better trophectoderm were significantly associated with an ongoing pregnancy. In case of deterioration in quality of individual embryos between day 3 and day 5, the OPR was significantly lower. Conversely, improvement of embryo quality between day 3 and day 5 showed higher ongoing pregnancy rates (overall OPR of good day-3 embryos improving to excellent day-5 embryos: 30 %; moderate day 3 to excellent day 5: 50 %; poor day 3 to excellent day 5: 42 %; poor day 3 to good day 5: 20 %; poor day 3 to moderate day 5: 16 %). When embryos improved from poor on day 3 to excellent day 5 the OPR was significantly higher in comparison with embryos that did not change in quality scoring during development (steady embryos) (OR: 1.785, p Conclusion Our results suggest that it is more likely to achieve an ongoing pregnancy when transferring an embryo that has improved in quality between days 3 and 5 as opposed to one that has remained stable. |
| Databáze: | OpenAIRE |
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