Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years

Autor: Nicholas Moore, Claudia Thieme, Alice Chandra Verticchio Vercellin, Joshua Gross, Priyanka Parekh, Scott Wentz, Brent Siesky, Rehan M. Hussain, Alon Harris
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Retinal Ganglion Cells
Intraocular pressure
medicine.medical_specialty
genetic structures
Retinal Artery
Diastole
Glaucoma
Ciliary Arteries
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Ophthalmic Artery
0302 clinical medicine
Nerve Fibers
medicine.artery
Ophthalmology
medicine
Laser-Doppler Flowmetry
Humans
Intraocular Pressure
Aged
business.industry
Retinal
Blood flow
Middle Aged
medicine.disease
eye diseases
Sensory Systems
Surgery
030104 developmental biology
chemistry
Regional Blood Flow
Ophthalmic artery
030221 ophthalmology & optometry
Optic nerve
Disease Progression
Population study
Visual Field Tests
Female
sense organs
Visual Fields
business
Blood Flow Velocity
Glaucoma
Open-Angle
Tomography
Optical Coherence
Follow-Up Studies
Zdroj: The British journal of ophthalmology. 101(3)
ISSN: 1468-2079
Popis: Background/aims Previous studies suggest that vascular abnormalities are involved in the pathogenesis of open-angle glaucoma. This study aims to examine the relationship of baseline retrobulbar blood flow measurements with functional and structural glaucomatous progression in patients with open-angle glaucoma over 4 years. Methods In this study, 112 patients with open-angle glaucoma were examined at baseline and 78 with retrobulbar blood flow assessments were followed to 4 years. Colour Doppler imaging was used to evaluate retrobulbar blood flow. Structural disease progression was examined with optical coherence tomography and Heidelberg Retinal Tomography III. Functional disease progression was monitored with automated perimetry using Humphrey visual fields. Mixed-model analysis of covariance was used to test for significance of changes from baseline to 4-year follow-up. Two-sample t tests and χ 2 tests were used to test for baseline blood flow differences between patients who progressed and those who did not progress. Results Patients who progressed structurally had a statistically significant lower baseline mean ophthalmic artery peak systolic velocity (PSV) (p=0.024) and ophthalmic artery end diastolic velocity (EDV) (p=0.012) compared with those who did not progress. Similarly, a lower baseline mean ophthalmic artery PSV (p=0.031) and ophthalmic artery EDV (p=0.005) were associated with patients who progressed functionally compared with those who did not progress after 4 years. Conclusions In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years.
Databáze: OpenAIRE
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