Effects of Nilvadipine on Cytokine-Levels and Soluble Factors in Collagen Disease Complicated with Essential Hypertension
| Autor: | Yoshio Ozaki, S. Fukuhara, S. Nomura, Minori Nagahama, Hideo Kagawa |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Nifedipine Physiology medicine.medical_treatment CD3 CD4-CD8 Ratio Blood Pressure Enzyme-Linked Immunosorbent Assay Lymphocyte Activation Essential hypertension T-Lymphocyte Subsets Internal medicine Internal Medicine medicine Humans Aged Retrospective Studies Collagen disease biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Collagen Diseases HLA-DR1 Antigen Interleukin Receptors Interleukin-2 T-Lymphocytes Helper-Inducer General Medicine Middle Aged Calcium Channel Blockers Flow Cytometry medicine.disease Nilvadipine Treatment Outcome Endocrinology Cytokine Hypertension biology.protein Cytokines Leukocyte Common Antigens Female Tumor necrosis factor alpha business CD8 Interleukin-1 medicine.drug |
| Zdroj: | Clinical and Experimental Hypertension. 21:1177-1188 |
| ISSN: | 1525-6006 1064-1963 |
| Popis: | We examined some immunological parameters, particularly cytokines and soluble factors in collagen diseases complicated with essential hypertension. We also investigated the effects of Nilvadipine on immunological parameters after treatment with this drug for six months. The frequency of helper/inducer T cells (CD4+ CD8- cells, CD4+ CD45RA- cells) decreased in the peripheral blood on a 6 month treatment with nilvadipine. There was a significant decrease of suppressor/inducer T cells (CD4+ 45RA+ cells), and an insignificant decrease of activated T cells (CD3+ HLA-DR+ cells) and memory T cells (CD45RA- CD45RO+ cells) after treatment. Before treatment with Nilvadipine, interleukin-1beta, tumor necrosis factor-a, and interleukin-6 levels increased higher in the patients than in healthy volunteers. However, interleukin-1beta and interleukin-6 concentrations tended to decrease after treatment with Nilvadipine. Besides, tumor necrosis factor-alpha decreased significantly after treatment. The soluble interleukin-2 receptor concentrations also showed a decreased tendency after treatment, although high concentrations were found in the patients before treatment. In contrast, soluble human leukocyte antigen-1 and soluble thrombomodulin levels showed no significant change after treatment. These results suggest that Nilvadipine inhibits the generation of cytokines derived from activated T lymphocytes. Nilvadipine, calcium antagonist, may be useful for inhibition of vascular complication in collagen diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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