The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers
| Autor: | David A. Antonetti, Carla Jhoana Ramos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Histology Review GTPase Biology Blood–brain barrier Biochemistry Cell junction 03 medical and health sciences Blood-Retinal Barrier medicine Animals Humans Barrier function Monomeric GTP-Binding Proteins Tight junction Cell Biology Acetylcysteine Erythromycin Cell biology Endothelial stem cell 030104 developmental biology medicine.anatomical_structure Transcytosis Blood-Brain Barrier Signal transduction Signal Transduction |
| Zdroj: | Tissue Barriers. 5:e1339768 |
| ISSN: | 2168-8370 |
| DOI: | 10.1080/21688370.2017.1339768 |
| Popis: | Maintenance and regulation of the vascular endothelial cell junctional complex is critical for proper barrier function of the blood-brain barrier (BBB) and the highly related blood-retinal barrier (BRB) that help maintain proper neuronal environment. Recent research has demonstrated that the junctional complex is actively maintained and can be dynamically regulated. Studies focusing on the mechanisms of barrier formation, maintenance, and barrier disruption have been of interest to understanding development of the BBB and BRB and identifying a means for therapeutic intervention for diseases ranging from brain tumors and dementia to blinding eye diseases. Research has increasingly revealed that small GTPases play a critical role in both barrier formation and disruption mechanisms. This review will summarize the current data on small GTPases in barrier regulation with an emphasis on the EPAC-Rap1 signaling pathway to Rho in endothelial barriers, as well as explore its potential involvement in paracellular flux and transcytosis regulation. |
| Databáze: | OpenAIRE |
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