Tamoxifen and Megestrol Acetate for Postmenopausal Breast Cancer: Diverging Effects on Liver Proteins, Androgens, and Glucocorticoids
| Autor: | Birgitta Wallberg, Lars-Erik Rutqvist, Tommy Fornander, B. von Schoultz, E. von Schoultz, L. Löfgren, K. Carlström, N. Wilking |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
medicine.medical_specialty Antineoplastic Agents Hormonal Anabolism Breast Neoplasms Breast cancer Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine Multicenter trial Antineoplastic Combined Chemotherapy Protocols medicine Humans Testosterone Prospective Studies Insulin-Like Growth Factor I Aged Hematology biology business.industry Megestrol Acetate General Medicine Middle Aged medicine.disease Postmenopause Tamoxifen Endocrinology Oncology Chemotherapy Adjuvant Megestrol acetate biology.protein Female business hormones hormone substitutes and hormone antagonists medicine.drug Blood sampling |
| Zdroj: | Medical Oncology. 21:309-318 |
| ISSN: | 1357-0560 |
| Popis: | Aim To compare the effects of tamoxifen and megestrol acetate on liver proteins, androgens, and glucocorticoids during adjuvant treatment for postmenopausal breast cancer. Methods A subgroup of women within a large prospective multicenter trial were followed with blood sampling every 3 mo during 2 yr. Women were randomized to receive either continuous tamoxifen 40 mg/d or repeated sequential treatment with tamoxifen and megestrol acetate (MA) 160 mg/d. Results We found profound and distinct differences between the two regimens. Tamoxifen increased steroid-binding proteins (SHBG and CBG) and suppressed circulating androgens and IGF-I. In contrast, the metabolic effects of tamoxifen were clearly antagonized by MA. There was a rise in IGF-I and marked suppression of steroid-binding proteins. Levels of free testosterone were reduced by 70%. MA also caused apparent adrenal suppression. Conclusion The different effects on anabolic/catabolic balance and adrenal function may relate to certain clinical effects during treatment. |
| Databáze: | OpenAIRE |
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