Reduced amygdalar and hippocampal size in adults with generalized social phobia
| Autor: | Godehard Weniger, Falk Leichsenring, Mirjana Ruhleder, Eva Irle, Eric Leibing, Ulrich Seidler-Brandler, Claudia Lange, Simone Salzer, Peter Dechent |
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| Přispěvatelé: | University of Zurich, Irle, E |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Oncology social phobia adult Hippocampus Comorbidity Hippocampal formation Severity of Illness Index Functional Laterality 2738 Psychiatry and Mental Health 0302 clinical medicine 2736 Pharmacology (medical) Pharmacology (medical) Sex Characteristics Brief Report Brain Organ Size Middle Aged Amygdala Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Phobic Disorders Major depressive disorder Female Psychology 2803 Biological Psychiatry Anxiety disorder Psychopathology Clinical psychology Adult medicine.medical_specialty 610 Medicine & health 10056 Clinic for Clinical and Social Psychiatry Zurich West (former) Personality Disorders Young Adult 03 medical and health sciences Imaging Three-Dimensional Neuroimaging Internal medicine medicine Humans Biological Psychiatry Psychiatric Status Rating Scales medicine.disease 030227 psychiatry 030217 neurology & neurosurgery |
| Popis: | Background: Structural and functional brain imaging studies suggest abnormalities of the amygdala and hippocampus in posttraumatic stress disorder and major depressive disorder. However, structural brain imaging studies in social phobia are lacking. Methods: In total, 24 patients with generalized social phobia (GSP) and 24 healthy controls underwent 3-dimensional structural magnetic resonance imaging of the amygdala and hippocampus and a clinical investigation. Results: Compared with controls, GSP patients had significantly reduced amygdalar (13%) and hippocampal (8%) size. The reduction in the size of the amygdala was statistically significant for men but not women. Smaller right-sided hippocampal volumes of GSP patients were significantly related to stronger disorder severity. Limitations: Our sample included only patients with the generalized subtype of social phobia. Because we excluded patients with comorbid depression, our sample may not be representative. Conclusion: We report for the first time volumetric results in patients with GSP. Future assessment of these patients will clarify whether these changes are reversed after successful treatment and whether they predict treatment response. |
| Databáze: | OpenAIRE |
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