Signals for proinflammatory cytokine secretion by human Schwann cells
| Autor: | Steven L. Kunkel, J. Lynn Rutkowski, Gerald F. Tuite, Philip J. Boyer, Gihan Tennekoon, Pamela M. Lincoln |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Wallerian degeneration medicine.medical_treatment Immunology Inflammation Biology Proinflammatory cytokine medicine Humans Immunology and Allergy Secretion Cells Cultured Chemokine CCL2 Interleukin-6 Growth factor Interleukin-8 Middle Aged medicine.disease Neuroregeneration Cell biology Cytokine medicine.anatomical_structure nervous system Neurology Peripheral nervous system Cytokines Female Schwann Cells Neurology (clinical) medicine.symptom Interleukin-1 |
| Zdroj: | Journal of Neuroimmunology. 101:47-60 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(99)00132-0 |
| Popis: | Wallerian degeneration is a post-traumatic process of the peripheral nervous system whereby damaged axons and their surrounding myelin sheaths are phagocytosed by infiltrating leukocytes. Our studies indicate that Schwann cells could initiate the process of Wallerian degeneration by releasing proinflammatory cytokines involved in leukocyte recruitment and differentiation including IL-1beta, MCP-1, IL-8 and IL-6. A comparison of the secretory pattern between nerve explants and cultured Schwann cells showed that each cytokine was differentially regulated by growth factor deprivation or axonal membrane fragments. Since Wallerian-like degeneration occurs in a wide variety of peripheral neuropathies, Schwann cell-mediated cytokine production may play an important role in many disease processes. |
| Databáze: | OpenAIRE |
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