Acute Effects of Pathogenic Simian-Human Immunodeficiency Virus Challenge on Vaccine-Induced Cellular and Humoral Immune Responses to Gag in Rhesus Macaques
| Autor: | Krista K. Steger, C. David Pauza, Paul M. Waterman |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
animal diseases viruses medicine.medical_treatment Viral pathogenesis Immunology Gene Products gag Biology Antibodies Viral Lymphocyte Activation medicine.disease_cause Microbiology Virus Immune system Immunity Virology medicine Animals SAIDS Vaccines Simian immunodeficiency virus Vaccine efficacy Macaca mulatta Immunization Insect Science Pathogenesis and Immunity Simian Immunodeficiency Virus Adjuvant |
| Zdroj: | Journal of Virology. 73:1853-1859 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.73.3.1853-1859.1999 |
| Popis: | Simian-human immunodeficiency virus (SHIV) infection in macaques provides a convenient model for testing vaccine efficacy and for understanding viral pathogenesis in AIDS. We immunized macaques with recombinant, Salmonella typhimurium (expressing Gag) or soluble Gag in adjuvant to generate T-cell-dependent lymphoproliferative or serum antibody responses. Immunized animals were challenged by intrarectal inoculation with SHIV89.6PD. Virus infection was accompanied by rapid losses of lymphoproliferative responses to Gag or phytohemagglutinin. By 8 weeks, mitogen responses recovered to near normal levels but antigen-specific immunity remained at low or undetectable levels. Serum antibody levels were elevated initially by virus exposure but soon dropped well below levels achieved by immunization. Our studies show a rapid depletion of preexisting Gag-specific CD4 + T cells that prevent or limit subsequent antiviral cellular and humoral immune responses during acute SHIV infection. |
| Databáze: | OpenAIRE |
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