Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese
| Autor: | Toshihiko Yanase, Noriyuki Sonoda, Hirotaka Tsubouchi, Haruo Takeda, Mitsuhiro Nakazaki, Iwaho Hazegawa, Kenziro Narazaki, Ken Yamamoto, Shoichi Akazawa, Hidekatsu Sugimoto, Junko Ono, Tomoko Sonoda, Eiichi Araki, Masayuki Aoki, Takehiko Sasazuki, Kohei Yamaguchi, Katsumi Eguchi, Toyoshi Inoguchi, Kazuki Yasuda, Hajime Nawata, Teruaki Yamauchi, Kazuyuki Hamaguchi, Nobuyuki Takasu, Masahiro Matsumoto, Yoshiya Tanaka, Takashi Asano, Naoto Keicho, Fumio Umeda, Masanori Iwase, Yasuko Ito, Naoki Nakashima, Senji Shirasawa, Jun Hashiguchi, Hironobu Yoshimatsu, Nakayasu Wake, Moritsugu Shinohara, Norihiro Kato, Takeshi Nishikawa, Seiho Nagafuchi, Seibei Miyake, Hideo Fukushima, Takashi Eto, Mayuko Ishikawa, Takayuki Sasahara, Toshimitsu Okeda |
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| Rok vydání: | 2004 |
| Předmět: |
Linkage (software)
Genetics endocrine system diseases Genetic Linkage Genome Human business.industry Chromosomes Human Pair 11 Type 2 Diabetes Mellitus medicine.disease Insulin resistance Diabetes Mellitus Type 2 Japan Genetic linkage Susceptibility locus medicine Humans Genetic Predisposition to Disease Lod Score business Genetics (clinical) Genome wide linkage Heterogeneous disorder Lod score |
| Zdroj: | Journal of Human Genetics. 49:629-634 |
| ISSN: | 1435-232X 1434-5161 |
| DOI: | 10.1007/s10038-004-0199-3 |
| Popis: | Type 2 diabetes mellitus is a heterogeneous disorder, and the development of type 2 diabetes mellitus is associated with both insulin secretion defect and insulin resistance. The primary metabolic defect leading to type 2 diabetes mellitus has been thought to be varied among populations, especially in Japanese and Caucasians. Here, we have done the genome-wide scan for type 2 diabetes mellitus using 102 affected Japanese sib-pairs to identify the genetic factors predisposing to type 2 diabetes mellitus. Nonparametric linkage analysis showed one suggestive evidence for linkage to 11p13-p12 [D11S905: two-point maximum LOD score (MLS) of 2.89 and multipoint MLS of 2.32] and one nominally significant evidence for linkage to 6q15-q16 (D6S462: two-point MLS of 2.02). Interestingly, the 11p13-p12 region was reported to be a susceptibility locus for Japanese type 2 diabetes mellitus with suggestive evidence of linkage, and D11S905 was within 5 cM to D11S935 with the highest MLS in the previous linkage analysis reported. The only overlapped susceptibility region with suggestive evidence of linkage for Japanese type 2 diabetes mellitus was D11S935-D11S905 among the three reports including this study. These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12. |
| Databáze: | OpenAIRE |
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