The Safety of Felodipine
| Autor: | S D Pringle, A R Lorimer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
medicine.medical_specialty Felodipine business.industry Vasodilation medicine.disease Angina Diabetes mellitus Heart failure Edema Internal medicine Hypertension medicine Palpitations Cardiology Animals Humans medicine.symptom Cardiology and Cardiovascular Medicine Adverse effect business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 15:S85-S89 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199015004-00026 |
| Popis: | Hypertensive patients, particularly the elderly, may often suffer from other diseases. Therefore, antihypertensive compounds should not negatively affect such disorders. Felodipine is a calcium antagonist that has potentially beneficial effects in angina pectoris and congestive heart failure. Further, it does not adversely affect lung function in asthmatic patients or glucose tolerance in patients with diabetes. Preliminary investigations also indicate that felodipine has no negative influence on plasma lipid levels. Although felodipine seems to be safe in most patients, treatment with felodipine should at present be avoided in pregnant women, since digital anomalies have been observed in rabbit fetuses. The adverse effects seen during treatment with felodipine are usually mild and transient and generally related to the vasodilatory action of the drug, the most common being ankle edema, headache, flushing, dizziness, and palpitations. The only significant drug interactions with felodipine occur with inducers and inhibitors of the cytochrome P-450 system, which is responsible for the metabolism of felodipine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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