CONTINUOUS INFUSION OF PYRIDOXALATED HEMOGLOBIN POLYOXYETHYLENE CONJUGATE IN HYPERDYNAMIC SEPTIC SHEEP
| Autor: | Hans G. Bone, Daniel L. Traber, Roy McGuire, Stefanie R. Fischer, Lillian D. Traber, Paul J. Schenarts |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Hemodynamics Blood Pressure Critical Care and Intensive Care Medicine Drug Administration Schedule Polyethylene Glycols Blood substitute Sepsis Hemoglobins Oxygen Consumption Intensive care Animals Infusions Intra-Arterial Medicine Pseudomonas Infections Lung Sheep Dose-Response Relationship Drug business.industry medicine.disease Surgery medicine.anatomical_structure Blood pressure Regional Blood Flow Anesthesia Pseudomonas aeruginosa Emergency Medicine Vascular resistance Female Hemoglobin business |
| Zdroj: | Shock. 10:69-76 |
| ISSN: | 1073-2322 |
| Popis: | Cell-free hemoglobin solutions can scavenge nitric oxide and therefore increase mean arterial pressure (MAP). The present study investigated the effects of a continuous low-dose infusion of modified hemoglobin during ovine hyperdynamic sepsis. 13 sheep received a continuous infusion of live Pseudomonas aeruginosa bacteria for 48 h. Animals that survived the first 24 h of sepsis (n=12) were randomly assigned either to a treatment group that received 20 mg x kg(-1) x h(-1) pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) for 20 h or to a control group that received the same volume of the vehicle for 20 h. MAP increased in the treatment group during 4 h of PHP infusion 12.7+/-1.7 mmHg (p < .05) and after 20 h of PHP infusion MAP was still 12.4+/-2.1 mmHg above the MAP before starting PHP (p < .05). MAP in the control group did not change significantly from 24 h to 48 h of sepsis. No differences in regional blood flow were seen between groups. Bacterial counts in the spleen and kidney were lower in the treatment group than in the control group. Continuous low-dose infusion of PHP can normalize systemic vascular resistance and MAP for long periods without deterioration of regional blood flow or bacterial clearance. |
| Databáze: | OpenAIRE |
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