Glutathione levels in blood from ataxia telangiectasia patients suggest in vivo adaptive mechanisms to oxidative stress
| Autor: | Kaan Kavakli, Emilia Vuttariello, Paola Manini, Paolo Degan, Federico V. Pallardó, Giovanni Pagano, Rita Calzone, Simona Cavalieri, Alfredo Brusco, Ana Lloret, Maria Antonietta Pisanti, Marco d'Ischia, Adriana Zatterale |
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| Přispěvatelé: | Degan, P, D'Ischia, Marco, Pallardo, F. V., Zatterale, A, Brusco, A, Calzone, R, Cavalieri, S, Kavakli, K, Lloret, A, Manini, Paola, Pisanti, M. A., Vuttariello, E, Pagano, G., PALLARDO F., V, PISANTI M., A |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent glyoxal Clinical Biochemistry ataxia telengiectasia medicine.disease_cause Ataxia Telangiectasia chemistry.chemical_compound In vivo Internal medicine methylglyoxal medicine Humans ataxia telangectasia oxidative stress glutathione Child oxidative stre Methylglyoxal Deoxyguanosine 8-Hydroxy-2'-deoxyguanosine Heterozygote advantage General Medicine Glutathione Pyruvaldehyde medicine.disease Adaptation Physiological Endocrinology chemistry Biochemistry Child Preschool Ataxia-telangiectasia Female Oxidative stress Target organ DNA Damage |
| Zdroj: | Clinical Biochemistry. 40:666-670 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2007.03.013 |
| Popis: | Objective: To evaluate an in vivo pro-oxidant state in patients with ataxia telangiectasia (AT). Methods: A set of oxidative stress endpoints were measured in 9 AT homozygotes, 16 AT heterozygotes (parents) and 83 controls (grouped in age ranges as for patients and parents, respectively). The following analytes were measured: (a) leukocyte 8-hydroxy-2-deoxyguanosine (8-OHdG); (b) blood glutathione (GSSG and GSH); and (c) plasma levels of glyoxal (Glx) and methylglyoxal (MGlx). Results: AT patients displayed a significant decrease in blood GSSG (p=0.012) and in MGlx plasma concentrations (P=0.012). A nonsignificant decrease in the GSSG:GSH ratio (p = 0.1) and a non-significant increase in 8-OHdG and Glx levels were observed in AT patients vs. young controls (age range 4-35 years). AT heterozygotes failed to display any significant changes vs. adult controls (age range 36-68 years). Conclusion: No significant increase in oxidative stress biomarkers was detected in blood from AT patients. The decrease in GSSG and MGlx levels in AT patients may suggest an adaptive response to a pro-oxidant state in AT-related target organs. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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