Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys
| Autor: | Melanie West, Michael Murphey-Corb, Ronald C. Montelaro, W. Abe Andes, Bobby J. Gormus, Gary B. Baskin, Louis N. Martin, S. R. S. Rangan, Robert H. Wolf |
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| Rok vydání: | 1986 |
| Předmět: |
T-Lymphocytes
viruses Enzyme-Linked Immunosorbent Assay Cross Reactions Simian Antibodies Viral Deltaretrovirus Macaque Virus Cell Line Retrovirus biology.animal Animals Humans Mangabey Acquired Immunodeficiency Syndrome Multidisciplinary biology Cercopithecidae biology.organism_classification Macaca mulatta Virology Molecular Weight Microscopy Electron Simian AIDS Immunology Sooty mangabey biology.protein Antibody |
| Zdroj: | Nature. 321:435-437 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/321435a0 |
| Popis: | Acquired immune deficiency syndrome (AIDS) has become a worldwide epidemic1–6, so the development of vaccines and antiviral agents effective against the causative agent, human T-lymphotropic virus type III (HTLV-III), is vital. This work would be greatly simplified if a suitable animal model could be developed. Here we report the isolation of an HTLV-III-related retrovirus, STLV-III/Delta, from rhesus macaques (Macaca mulatta) with transmissible simian AIDS (SAIDS) and from asymptomatic sooty mangabeys (Cercocebus atys). SAIDS was initially diagnosed in several macaques previously inoculated with tissue homogenates of mangabey origin. Western blot analysis of both the mangabey and macaque sera demonstrated the presence of antibody cross-reactive primarily with the HTLV-III proteins p24 and p61. In a related experiment, analysis of these same sera revealed simian antibody to STLV-III/Delta proteins similar, but not identical, to those of HTLV-III with estimated relative molecular masses (Mrs) of 16,000 (16K), 26K, 35K, 45K, 60K and 110K. Infection of the mangabey, an African primate, with an HTLV-III-related virus may provide a clue to the origin of HTLV-III in humans. The apparent difference in susceptibility to SAIDS-like disease between infected macaques and mangabeys suggests that these species may respond differently to STLV-III infection. |
| Databáze: | OpenAIRE |
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