The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage
| Autor: | C Stefanadis, K Dimitriadis, Pavlos Toutouzas, Ioannis Kallikazaros, D Chatzis, Dimitris Antoniadis, Costas Tsioufis, S Lalos, Elena Vezali, Alexandra I. Zervoudaki |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Left ventricular hypertrophy Essential hypertension Severity of Illness Index Body Mass Index chemistry.chemical_compound Nephelometry and Turbidimetry Internal medicine Outpatients Internal Medicine Albuminuria Humans Medicine Retrospective Studies business.industry Serum uric acid Middle Aged medicine.disease Target organ damage Uric Acid Endocrinology chemistry Echocardiography Hypertension Regression Analysis Uric acid Female Hypertrophy Left Ventricular Microalbuminuria business Biomarkers Target organ Follow-Up Studies |
| Zdroj: | Journal of Human Hypertension. 19:211-217 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/sj.jhh.1001810 |
| Popis: | The role of serum uric acid (SUA) in the context of adverse cardiovascular events in hypertensive subjects is controversial. Additionally, the relationship between SUA and indices of target organ damage is not well defined in this setting. Towards this end, we studied 842 consecutive nondiabetic patients with stage I-II essential hypertension (office blood pressure=148/95 mmHg, aged 53.4 years), referred to our outpatient hypertensive unit within a period of 4 years. According to the urinary albumin excretion (UAE), the study population was classified into those with microalbuminuria [MA(+), UAE=20-200 mg/24 h, n=222] and those without MA [MA (-), UAE20 mg/24 h, n=620]. Moreover, according to the presence of left ventricular hypertrophy (LVH) the participants were subdivided into two additional groups: [LVH (+), n=305 and LVH (-), n=537]. SUA levels were higher by 0.4 mg/dl, (P=0.04) in group MA (+) compared with the group MA (-), while no difference was observed between groups LVH (+) and LVH (-) (P=NS). In the entire population, SUA was correlated with body mass index (BMI) (r=0.17, P0.001), waist/hip ratio (r=0.3, P0.001), office systolic blood pressure (SBP) (r=0.14, P0.05), triglycerides levels (r=0.25, P0.001), UAE (r=0.35, P0.001) and HDL (r=-0.26, P0.001). Multiple regression analysis demonstrated that SUA was significantly related with BMI, office SBP and UAE (P0.05). In conclusion, increased SUA levels are associated with MA but not with LVH in essential hypertensive subjects. Whether these inter-relationships may elucidate the clinical positioning of augmented SUA in this setting remains to be clarified in future studies. |
| Databáze: | OpenAIRE |
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