Severe insomnia is associated with metabolic syndrome in women over 50 years with major depression treated in psychiatry settings: a METADAP report
| Autor: | Emmanuelle Corruble, Abd El Kader Ait Tayeb, Jean-François Costemale-Lacoste, Séverine Martin, Khalil El Asmar, Romain Colle, Adrien Rigal, Laurent Becquemont, Bruno Fève |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Population Logistic regression 03 medical and health sciences 0302 clinical medicine Sleep Initiation and Maintenance Disorders Internal medicine mental disorders Insomnia Humans Medicine education Depression (differential diagnoses) Metabolic Syndrome Psychiatry Depressive Disorder Major education.field_of_study Depression business.industry Hypertriglyceridemia Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cohort Major depressive disorder Female medicine.symptom Metabolic syndrome business Azo Compounds 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 264:513-518 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2019.11.084 |
| Popis: | Introduction Major depression is associated with metabolic syndrome and cardiovascular risk. We have previously shown that severe insomnia, a core symptom of major depression episode (MDE), is associated with hypertriglyceridemia, a component of metabolic syndrome, in women but not in men with major depression. Since insomnia is related to cardiovascular morbidity in the general population and major depression also, our objective was to assess the link between insomnia and metabolic syndrome, a marker syndrome of cardiovascular risk, during MDE, in women and in men. Methods In 624 patients with a current MDE cohort, both insomnia and metabolic syndrome were assessed in women and men. Insomnia was rated from 0 to 6 based on the HDRS corresponding items, severe insomnia being defined by a total insomnia score ≥4. Results severe insomnia was associated with metabolic syndrome in women but not in men. In multivariate logistic regressions, these results in women were independent from age, educational level, major depressive disorder duration and current smoking. These results were only significant in women aged ≥50 years, a cut-off age for menopausal status but not in women under 50 years. Conclusion Women aged ≥50 years with a severe insomnia during MDE have an increased risk of metabolic syndrome. Severe insomnia may be a clinical marker of metabolic risk in this population. They should be particularly monitored for metabolic syndrome and may benefit from sleep recommendations and cardiovascular prevention. |
| Databáze: | OpenAIRE |
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