Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
| Autor: | Antonia Serrano, Jesús Aranda, Daniel Silva-Peña, Juan Jesús Ruiz, Nerea Requena-Ocaña, Fernando Rodríguez de Fonseca, Nuria García-Marchena, Juan Suárez, María Flores, Patricia Rivera, Pedro Araos, Francisco Javier Pavón |
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| Přispěvatelé: | [Requena-Ocaña,N, Araos,P, Flores,M, García-Marchena,N, Silva-Peña,D, Aranda,J, Rivera,P, Serrano,A, Pavón,FJ, Suárez,J, Rodríguez de Fonseca,F] Mental Health Clinical Management Unit, Institute of Biomedical Research of Malaga-IBIMA, Regional University. [Requena-Ocaña,N] School of Psychology, Complutense University of Madrid, Madrid, Spain. [Araos,P] Department of Psychobiology and Methodology of Behavioral Sciences, School of Psychology, University of Málaga, Málaga, Spain. [Aranda,J] School of Medicine, University of Málaga, Málaga, Spain. [Ruiz,JJ] Provincial Drug Addiction Center of Málaga, Provincial Council of Málaga, Málaga, Spain. [Pavón,FJ] Cardiac Clinical Management Unit, IBIMA, University Hospital Virgen de la Victoria, Málaga, Spain. [Suárez,J] Department of Human Anatomy, Legal Medicine and History of Science, IBIMA, Facultad de Medicina, University of Málaga, Málaga, Spain. [Requena-Ocaña,N] Laboratorio de Investigación, IBIMA, Hospital Universitario Regional de Málaga, Málaga, Spain., The authors state having received the following fnancial support for the research, authorship and/or publication of this article: the present study was supported by the following research programs and projects: RETICS Networks Subprogram (Addictive Disorders Network, RD16/0017/0001 and RD16/0017/0021) funded by the Carlos III Health Institute (ISCIII), Ministry of Economy and Competitiveness (MINECO) and the European Regional Development Fund/European Social Fund (FEDER/ESF), Health Research Projects (PI16/01577, PI16/01689, PI17/02026 and PI19/00886) funded by ISCIII and FEDER/FSE, Research Projects in Drug Addiction (PND2017/043, PND2018/033, PND2018/044 and PND2019/040) funded by the Government Delegation for the National Plan on Drugs, Ministry of Health, Social Services and Equality and FEDER/FSE, Health Research Project (PI-0140-2018) funded by the Ministry of Health and Social Welfare, Regional Government of Andalucía and FEDER/FSE. MF has a predoctoral research contract PFIS (F18/00249) funded by the ISCIII. NGM has a 'Sara Borrell' research contract (CD19/00019) funded by ISCIII and FEDER-UE. AS, JS and FJP have a 'Miguel Servet' research contract (CPII19/00031, CPII17/00024 and CPII19/00022, respectively) funded by ISCIII and FEDER-UE. PA has a research contract (UMA-FEDERJA-076) funded by the Ministry of Economy and Knowledge—Regional Government of Andalucía and FEDER-UE. |
| Rok vydání: | 2021 |
| Předmět: |
Male
Psychological intervention 030508 substance abuse Alcohol use disorder Comorbidity Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Principal Component Analysis [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] 0302 clinical medicine Cognitive Reserve Neurotrophin 3 Neurotrophic factors Persons::Persons::Men::Nurses Male [Medical Subject Headings] Psychology Cognitive decline Insulin-Like Growth Factor I Cognitive reserve Principal Component Analysis Multidisciplinary Alcohol Abstinence Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Nerve Growth Factors::Brain-Derived Neurotrophic Factor [Medical Subject Headings] Cognition Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Somatomedins::Insulin-Like Growth Factor II [Medical Subject Headings] Middle Aged Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Comorbidity [Medical Subject Headings] Alcoholism Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Somatomedins::Insulin-Like Growth Factor I [Medical Subject Headings] Medicine Educational Status Female 0305 other medical science Clinical psychology Alcohol Drinking Science Neurociencias Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism [Medical Subject Headings] Context (language use) Article 03 medical and health sciences Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Carrier Proteins::Insulin-Like Growth Factor Binding Proteins::Insulin-Like Growth Factor Binding Protein 3 [Medical Subject Headings] Insulin-Like Growth Factor II medicine Humans Cognitive Dysfunction business.industry Brain-Derived Neurotrophic Factor Alcohol dependence Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] medicine.disease Health Care::Population Characteristics::Socioeconomic Factors::Educational Status [Medical Subject Headings] Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Abstinence [Medical Subject Headings] Psicología Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition::Cognitive Reserve [Medical Subject Headings] Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis [Medical Subject Headings] Biomarcadores Insulin-Like Growth Factor Binding Protein 3 Check Tags::Female [Medical Subject Headings] ROC Curve Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings] Multivariate Analysis business 030217 neurology & neurosurgery Biomarkers Neuroscience |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function. |
| Databáze: | OpenAIRE |
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