Assessing the non-motor symptoms of Parkinson's disease: MDS-UPDRS and NMS Scale
| Autor: | José-Manuel Rojo-Abuín, Kallol Ray Chaudhuri, Pablo Martinez-Martin, Glenn T. Stebbins, Mayela Rodríguez-Violante, Monica M. Kurtis, Jing Huang, Tomoko Arakaki, Mario Alvarez-Sanchez, Henry Moore, Nelida Garretto, Amelia Mendoza-Rodriguez, Barbara C. Tilley, Anabel Chade, Juan Carlos Martínez-Castrillo, Carlos Singer, Carmen Rodriguez-Blazquez, Alberto Bergareche-Yarza, Christopher G. Goetz, Oscar S. Gershanik |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Psychometrics Spearman's rank correlation coefficient Severity of Illness Index Developmental psychology Correlation Rating scale Internal medicine Activities of Daily Living medicine Humans Aged Aged 80 and over business.industry Parkinson Disease Middle Aged medicine.disease Concordance correlation coefficient Cross-Sectional Studies Neurology Convergent validity Observational study Female Neurology (clinical) business Unit-weighted regression |
| Zdroj: | European journal of neurology. 22(1) |
| ISSN: | 1468-1331 |
| Popis: | Background and purpose Although Parkinson's disease (PD) is characterized by typical motor manifestations, non-motor symptoms (NMS) are an outstanding part of the disease. At present, several specific instruments for assessment of NMS are available. The objective of our study was to determine the performance of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Part I – Non-Motor Aspects of Experiences of Daily Living (nM-EDL) compared with the Non-Motor Symptoms Scale (NMSS). Methods To this purpose, 434 consecutive patients with PD were included in an international, observational, cross-sectional study. The association between scores of both scales was determined by the Spearman rank correlation coefficient. Equations for transformation of total score of a scale to the other were constructed from weighted regression models and both, transformed and observed score, contrasted by means of the Lin's Concordance Correlation Coefficient (LCCC) and Bland–Altman plot. Results As a whole, the prevalence of the NMS according to each scale was quite similar, and most of the correlations between their corresponding components were high (rS > 0.60). The total score correlation of the MDS-UPDRS Part I with the NMSS was high (rS = 0.81). Concerning the transformed scores, estimated scores only partially approach the observed ones (sharing about 60–64% of the variance) because residual variance increased with increasing magnitudes of the scores, i.e. the most severe patients (Bland–Altman plot; LCCC |
| Databáze: | OpenAIRE |
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