Renal function and novel urinary biomarkers in infants with neonatal encephalopathy
| Autor: | John F A Murphy, Chike Onwuneme, Amanda O'Neill, Eleanor J. Molloy, William Watson, Deirdre Sweetman |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Tamm–Horsfall protein Urinary system Encephalopathy Renal function Severity of Illness Index Gastroenterology 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal 030225 pediatrics Internal medicine medicine Humans 030212 general & internal medicine Asphyxia Neonatorum Brain Diseases biology business.industry Neonatal encephalopathy Infant Newborn Acute kidney injury General Medicine Acute Kidney Injury medicine.disease Perinatal asphyxia Surgery ROC Curve Case-Control Studies Pediatrics Perinatology and Child Health biology.protein Female business Ireland Biomarkers Kidney disease |
| Zdroj: | Acta Paediatrica. 105:e513-e519 |
| ISSN: | 0803-5253 |
| DOI: | 10.1111/apa.13555 |
| Popis: | Aim Perinatal asphyxia is associated with multi-organ injury including acute kidney injury (AKI). New urinary biomarkers may detect more subtle renal injury. Methods Urinary biomarkers (Albumin, Beta-2-Microglobulin, Cystatin-C, Epidermal-Growth-Factor, Neutrophil-Gelatinase-Associated-Lipocalin, Osteopontin, Uromodulin) were serially measured from day 1-7 in term infants with perinatal asphyxia and controls and compared to “Kidney Disease Improving Global Outcome” scoring of renal injury and to encephalopathy grade. Results Infants exposed to perinatal asphyxia(n=82) and term controls(n=10) had 255 urine samples taken. Thirty-nine infants underwent therapeutic hypothermia, 4 died and 30 infants had acute kidney injury. Infants with acute kidney injury had significantly higher levels of urinary Albumin(Day 2), Cystatin-C(Day 1,2,3 and 7), Neutrophil-Gelatinase-Associated-Lipocalin(Day 2,3 and 7) and Osteopontin(Day 2,3 and 7) and lower Epidermal-Growth-Factor and Uromodulin(Day 1) compared to those without AKI. Day 2 Cystatin-C predicted AKI with an area-under-receiver-operating-characteristic-curve of 0.89, p |
| Databáze: | OpenAIRE |
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