Cytotoxic lymphocytes in B-cell chronic lymphocytic leukemia
| Autor: | Jan Greve, de Bart G. Grooth, Ine M.J. Segers-Nolten, Leon W.M.M. Terstappen |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Pathology medicine.medical_specialty CD3 Complex CD8 Antigens Chronic lymphocytic leukemia Receptors Antigen T-Cell Bone Marrow Cells CD57 Antigens Internal medicine Leukemia B-Cell medicine Humans Cytotoxic T cell Lymph node Aged Aged 80 and over Hematology business.industry General Medicine T lymphocyte Middle Aged Flow Cytometry medicine.disease Leukemia Lymphocytic Chronic B-Cell Leukemia medicine.anatomical_structure CD4 Antigens Immunology Lymph Nodes Lymph Bone marrow business T-Lymphocytes Cytotoxic |
| Zdroj: | Blut. 60:81-87 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf01720512 |
| Popis: | The occurrence of cytotoxic lymphocyte subpopulations (i.e., CD 16+, CD 57+ and cytotoxic CD 8+) wa studied in the peripheral blood of 18 B-cell chronic lymphocytic leukemia (B-CLL) patients. The absolute numbers of CD 57+, CD 16+ and cytotoxic CD 8+ lymphocytes were increased in the peripheral blood of untreated patients as compared with healthy donors, suggesting a causal relation with the accumulation of malignant B-cells. For 5 B-CLL patients and 5 hematological normal donors, the lymphocyte subpopulations in peripheral blood, lymph nodes and bone marrow were determined. A significant immune response was observed in the lymph nodes of the patients, as reflected by the CD 3+ lymphocytes, which were 1.7-27 times larger in the patients lymph nodes than in their peripheral blood and bone marrow. In contrast, with peripheral blood this was mainly caused by an increase in CD 4+ lymphocytes. The CD 57 lymphocytes in the lymph nodes of the patients had abnormal orthogonal light-scattering signals and an abnormal density of CD 57+ receptors in comparison with their peripheral blood CD 57+ lymphocytes or the CD 57+ lymphocytes in the peripheral blood, bone marrow and tonsils of the hematological normal donors. This study shows that although a significant increase of cytotoxic lymphocytes in the peripheral blood of B-CLL patients is observed, the actual distributions of the non-malignant lymphocytes can be quite different at the actual tumor sites, i.e., bone marrow and lymph nodes. |
| Databáze: | OpenAIRE |
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