Regulators of G protein signaling in cardiovascular function during pregnancy
| Autor: | Mark K. Santillan, Katherine J Perschbacher, Guorui Deng, Justin L. Grobe, Rory A. Fisher, Katherine N. Gibson-Corley |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology G protein Disease Review Biology Cardiovascular control Polymorphism Single Nucleotide Receptors G-Protein-Coupled Cardiovascular Physiological Phenomena 03 medical and health sciences Regulator of G protein signaling Pregnancy Genetics medicine Animals Humans RGS2 fungi Receptor signaling medicine.disease Cell biology 030104 developmental biology Female Function (biology) RGS Proteins Protein Binding Signal Transduction |
| Zdroj: | Physiological genomics. 50(8) |
| ISSN: | 1531-2267 |
| Popis: | G protein-coupled receptor signaling mechanisms are implicated in many aspects of cardiovascular control, and dysfunction of such signaling mechanisms is commonly associated with disease states. Investigators have identified a large number of regulator of G protein signaling (RGS) proteins that variously contribute to the modulation of intracellular second-messenger signaling kinetics. These many RGS proteins each interact with a specific set of second-messenger cascades and receptor types and exhibit tissue-specific expression patterns. Increasing evidence supports the contribution of RGS proteins, or their loss, in the pathogenesis of cardiovascular dysfunctions. This review summarizes the current understanding of the functional contributions of RGS proteins, particularly within the B/R4 family, in cardiovascular disorders of pregnancy including gestational hypertension, uterine artery dysfunction, and preeclampsia. |
| Databáze: | OpenAIRE |
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