Activation of cannabinoid type 1 receptors decreases the synchronization of local field potential oscillations in the hippocampus and entorhinal cortex and prolongs the interresponse time during a differential‐reinforcement‐of‐low‐rate task

Autor:	Yi‐Tse Hsiao, Chao‐Lin Chang, Wan‐Ting Liao
Rok vydání:	2020
Předmět:	Agonist Cannabinoid receptor medicine.drug_class medicine.medical_treatment Hippocampus Local field potential Biology Hippocampal formation behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Receptor Cannabinoid CB1 medicine Animals Entorhinal Cortex Receptors Cannabinoid 030304 developmental biology 0303 health sciences Cannabinoids musculoskeletal neural and ocular physiology General Neuroscience Neurophysiology Entorhinal cortex Rats Cannabinoid Reinforcement Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery
Zdroj:	European Journal of Neuroscience. 52:4249-4266
ISSN:	1460-9568 0953-816X
DOI:	10.1111/ejn.14856
Popis:	Marijuana intoxication impairs neurocognitive functions. Common side effects of consuming cannabis include time distortion and memory loss. However, the underlying neurophysiological mechanisms involved in these effects remain unclear. We hypothesized that communication between the hippocampal CA1 region and medial entorhinal cortex (MEC) is essential for the transmission of temporal-associated information. We used a differential-reinforcement-of-low-rate (DRL) task, which requires subjects to press a lever at an optimal time point, to correlate the distributions of interresponse time (IRT) with local field potentials (LFPs) recorded in the CA1 and MEC under the effects of a cannabinoid type 1 (CB1) receptor agonist. We used a DRL 10-s schedule and trained the rats to withhold for 10 s before pressing a lever. Our data showed that the percentage of 12.4- to 14-s IRT events rose after activation of CB1 receptors in the MEC. In addition, gamma amplitude synchronization and CA1 theta phase-MEC gamma amplitude coupling decreased during the 6- to 14-s IRT events. These results suggest that activation of CB1 receptors in the MEC disrupt the functional connectivity between the CA1 and the MEC. This inefficient communication may result in increased IRT during a DRL schedule. Overall, we postulate that marijuana intoxication impairs the communication between the CA1 and MEC and influences behavioral performances that require precise timing ability.
Databáze:	OpenAIRE
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