| Autor: |
Melisa Hermet, Yanis Ricardo Espinosa, María Elisa Fait, Yenisleidy de las M. Zulueta Díaz, Susana Morcelle, Laura S. Bakás, H. Ariel Ariel Alvarez, María Laura Fanani |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of colloid and interface science. 631 |
| ISSN: |
1095-7103 |
| Popis: |
Amino acid-based surfactants have been proposed as skin permeation enhancers. In this work, we investigated the potentiality of two arginine-based amphiphiles as permeation enhancers by studying their interaction with stratum corneum (SC) model lipid membranes.NThe arginine-based amphiphiles studied were able to be incorporated into the SCM membrane and alter its rheological and structural properties by disordering the lipid chains, enhancing membrane elasticity, and thinning the overall membrane. They also affected the lateral structure of heterogeneous SC membranes at the nanoscale by relaxing and rounding the domain borders. Our work shows that the alteration observed of the overall rheological and structural properties of the SC membranes appears to be a shared ability for several amphiphilic permeation enhancers. Our results encourage future exploration of those amphiphiles as skin permeation enhancers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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