An Alternative 'Trojan Horse' Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology
| Autor: | Gianna Dipalma, Cao Diem Kiew Nguyen, Sergey K. Aityan, Rita Lazzaro, Pietro Distratis, Pham Hung Van, Antonia De Michele, Francesco Inchingolo, Felice Amatulli, Luigi Santacroce, Angelo Cefalo, Mario Giosuè Balzanelli, Marilina Tampoia, Davide Palazzo, Orazio Catucci, Ciro Gargiulo Isacco |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty ARDS Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Cross immunity Disease Biology 03 medical and health sciences 0302 clinical medicine Internal medicine Case fatality rate medicine Immunology and Allergy Animals Humans COPD SARS-CoV-2 COVID-19 medicine.disease Immunity Innate Interleukin-10 Systemic inflammatory response syndrome 030104 developmental biology Atypical pneumonia Etiology |
| Zdroj: | Endocrine, metabolicimmune disorders drug targets. 22(1) |
| ISSN: | 2212-3873 |
| Popis: | Abstract: The coronavirus disease 2019 (COVID-19) pandemic has been a challenge for emergency care units worldwide due to the large numbers of patients, the scarcity of information, the medical resources, and the uncertainty regarding the disease's etiology and pathogenesis. The transmission of the virus and a probable post-pandemic of SARS-CoV-2 will depend on how deep this disease, the duration of immunity and the degree of cross immunity between SARS-CoV-2 and other pathogens either bacteria or fungi can be understood. Most mortalities have been related to an atypical pneumonia consisted of a sudden worsening of general condition of the admitted positive COVID-19 patients. The severe thromboembolism, often characterized by violent pulmonary and systemic complications, have been described with a blend of inflammatory-infectious patterns that rapidly shifted into a typical systemic inflammatory response syndrome (SIRS) or into an acute respiratory distress syndrome (ARDS) that eventually concluded into a multi-organ failure (MOF) and death. The fatality rate reported in our Covid-19 structure, SG Moscati Hospital of Taranto province in Italy, was higher in elderly male people with preexisting chronic pulmonary disease (COPD), patients with cancer and preexisting cardio-vascular diseases (CVD). We assumed a different theoretical position to clarify the higher mortality seen among those patients that was not as obvious as it appeared, we thus offered different pathophysiological picture that could help to recent solutions in therapy and prevention. |
| Databáze: | OpenAIRE |
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