Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals

Autor: Cai-Nan Luo, Jialin Teng, Zhiqiang Li, Juan Zhou, Xuan Yuan, Yongyong Shi, Chengde Yang, Meihang Li, Yonghe Ding, Lin He, Hui Shi, Xingwang Li, Jian Xu, Yuanchao Sun, Zhaowei Zhou, Lin-Jie Chen, Huihui Chi, Yujuan Niu, Ting-Ting Ding, Jianhua Chen, Junna Ye, Ke Wang, Dun Pan, Xiaobing Cheng, Haitao Niu, Ting Zeng, Lijun Wu, Shuang Liu, Qiongyi Hu, Yue Sun, Chengwen Gao, Zhuochao Zhou, Jue Ji, Yutong Su, Honglei Liu, Changgui Li, Kuerbanjiang Yimaiti, Dong Wang
Rok vydání: 2019
Předmět:
Zdroj: Annals of the Rheumatic Diseases
ISSN: 1468-2060
0003-4967
Popis: Adult-onset Still's disease (AOSD) is a rare autoinflammatory condition with unclear aetiology and highly heterogeneous manifestations, such as spiking fever, skin rash and arthralgia (or arthritis).1 2 AOSD is usually the result of both genetic and environmental factors. However, only a few genetic loci have been associated with AOSD, and none of them have reached the threshold for genome-wide significance (GWS) of p
Databáze: OpenAIRE