Evaluation of the immunogenicity and safety of an indigenously developed DTwP-Hib tetravalent combination vaccine (Shan 4) with EasyFourTM in Indian infants administered per EPI schedule
| Autor: | S Narasimha Rao, Nitin Shah, Raman K. Rao, M Muzaffaruddin, Swarnarekha Bhat, Harish R Parikh, Veena Kalra, Rajan Joshi, Mandeep S Dhingra, G R Sethi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Fever Immunology Immunization Secondary India Pain complex mixtures law.invention Randomized controlled trial law Internal medicine medicine Edema Humans General Pharmacology Toxicology and Pharmaceutics Adverse effect Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines biology business.industry Immunogenicity Vaccination Toxoid Infant Antibodies Bacterial Research Papers Clinical trial Immunization biology.protein Female Antibody business |
| Zdroj: | Human Vaccines. 6:572-577 |
| ISSN: | 1554-8619 1554-8600 |
| DOI: | 10.4161/hv.6.7.11817 |
| Popis: | The study was planned to assess and compare immunogenicity and safety of an indigenous DTPw-Hib combination vaccine (Shan 4) with EasyFour, the available DTwP-Hib vaccine in India. Overall 210 healthy infants, six to eight weeks of age, were randomized to receive three doses of either Shan 4 or EasyFour at 6, 10 and 14 weeks of age. Antibodies were analyzed prior to and four to six weeks post third vaccine dose. Solicited and unsolicited local and systemic events in the follow up period after each dose were recorded. Post vaccination 100% of the infants in Shan 4 and EasyFour groups had seroprotective concentrations of Anti PRP-T IgG antibodies, IgG anti-diphtheria toxoid antibodies and IgG anti-tetanus toxoid antibodies. Following third dose of vaccination 86.99% subjects in the Shan 4 group and 73.85% subjects in the EasyFour group seroconverted for anti-pertussis antibody titres. Two Serious Adverse Events (SAE s) were reported during the course of the study, all unrelated to the respective vaccine administered. Most commonly reported adverse events in both the groups were pain at injection site, mild fever ( |
| Databáze: | OpenAIRE |
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