Identification of New Compounds from Sage Flowers (Salvia officinalis L.) as Markers for Quality Control and the Influence of the Manufacturing Technology on the Chemical Composition and Antibacterial Activity of Sage Flower Extracts
| Autor: | Martin Kaiser, Tilo Lübken, Diana Wolf, Sebastian Gericke, Karl Speer, Christian Hannig |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Quality Control
0301 basic medicine food.ingredient Lavandula Flowers Chemical Fractionation Salvia 01 natural sciences High-performance liquid chromatography Mass Spectrometry Carnosol 03 medical and health sciences chemistry.chemical_compound food X-Ray Diffraction Salvia officinalis Chromatography High Pressure Liquid biology Traditional medicine Plant Extracts 010405 organic chemistry SAGE food and beverages General Chemistry biology.organism_classification food.food Anti-Bacterial Agents 0104 chemical sciences 030104 developmental biology chemistry Herb General Agricultural and Biological Sciences Antibacterial activity |
| Zdroj: | Journal of Agricultural and Food Chemistry. 66:1843-1853 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.8b00581 |
| Popis: | Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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