Comparison of pharmacokinetics of sodium and lysine cephalexin in calves
| Autor: | A. Invernizzi, S. Carli, G. Perretta, R. Faustini, T. Brusa |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Pharmacology Blood level Cephalexin Chromatography General Veterinary Chemistry Sodium Lysine chemistry.chemical_element bacterial infections and mycoses Body weight Injections Intramuscular Kinetics Lysine cephalexin stomatognathic system Pharmacokinetics Injections Intravenous otorhinolaryngologic diseases polycyclic compounds Animals Distribution (pharmacology) Cattle Dose rate |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 6:181-185 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1111/j.1365-2885.1983.tb00462.x |
| Popis: | The pharmacokinetics of sodium and lysine cephalexins were investigated after intravenous and intramuscular administration of a single dose rate of 30 mg.kg-1 body weight in calves. The data for the two salts administered intravenously were pooled, the resulting pharmacokinetic disposition of cephalexin indicating a distribution half-time (t1/2α) and an elimination half-time (t1/2β) of 9.78 and 62.0 min, respectively. Following intramuscular administration some pharmacokinetic differences were recorded between the cephalexin preparations: lysine cephalexin was more rapidly eliminated (t1/2kel= 55.2 min) than sodium cephalexin (t1/2kel= 89.8 min), although the peak blood level was higher and attained after a longer time with lysine cephalexin. |
| Databáze: | OpenAIRE |
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