Pregnancy prevents hypertensive remodeling and decreases myogenic reactivity in posterior cerebral arteries from Dahl salt-sensitive rats
| Autor: | Marilyn J. Cipolla, Gerda G. Zeeman, Annet M. Aukes, Lisa Vitullo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
hypertension Physiology brain FLOW Pregnancy Complications Cardiovascular Cerebral arteries Blood Pressure Gestational Age Posterior cerebral artery PRESSURE Preeclampsia gestation Pregnancy Physiology (medical) Internal medicine medicine.artery medicine Animals Eclampsia Sodium Chloride Dietary OXIDATIVE STRESS INNERVATION Posterior Cerebral Artery Rats Inbred Dahl biology business.industry BLOOD-BRAIN-BARRIER ENCEPHALOPATHY medicine.disease GENE Rats Nitric oxide synthase Disease Models Animal PREECLAMPSIA Blood pressure Endocrinology OXIDE SYNTHASE INHIBITION MIGRAINE Vasoconstriction Cerebrovascular Circulation Circulatory system biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology, 292(2), H1071-H1076. AMER PHYSIOLOGICAL SOC |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Previous studies have demonstrated that pregnancy prevents protective hypertension-induced remodeling of cerebral arteries using nitric oxide synthase (NOS) inhibition to raise mean arterial pressure (MAP). In the present study, we investigated whether this effect of pregnancy was specific to NOS inhibition by using the Dahl salt-sensitive (SS) rat as a model of hypertension. Nonpregnant ( n = 16) and late-pregnant ( n = 17) Dahl SS rats were fed either a high-salt diet (8% NaCl) to raise blood pressure or a low-salt diet ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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