Relation of homocysteinemia to contrast-induced nephropathy in patients undergoing percutaneous coronary intervention
| Autor: | Myeong Ki Hong, Seung Jun Kim, Seung Hyeok Han, Young Guk Ko, Jung Sun Kim, Yangsoo Jang, Tae Hyun Yoo, Shin Wook Kang, Donghoon Choi, Kyu Hun Choi, Byung Keuk Kim |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Acute coronary syndrome Time Factors Homocysteine medicine.medical_treatment Contrast-induced nephropathy Myocardial Infarction Renal function Contrast Media Coronary Angiography chemistry.chemical_compound Internal medicine Triiodobenzoic Acids medicine Humans Risk factor Angioplasty Balloon Coronary Aged Retrospective Studies business.industry Percutaneous coronary intervention Odds ratio Middle Aged medicine.disease Prognosis female genital diseases and pregnancy complications chemistry Cardiology Female Kidney Diseases Cardiology and Cardiovascular Medicine business Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | The American journal of cardiology. 108(8) |
| ISSN: | 1879-1913 |
| Popis: | Hyperhomocysteinemia induces oxidative stress and endothelial dysfunction, which share the proposed pathophysiologic mechanisms of contrast-induced nephropathy (CIN). However, no study has investigated the relation between hyperhomocysteinemia and CIN. The aim of the present study was to evaluate the effects of hyperhomocysteinemia on CIN in patients undergoing percutaneous coronary intervention. This was an observational cohort study that included 572 patients who underwent percutaneous coronary intervention. CIN was defined as an absolute ≥0.5 mg/dl or a relative ≥25% increase in the serum creatinine level at 48 hours after the procedure. The incidence of CIN was significantly greater in patients in the third homocysteine tertile (from lowest to highest, 4.7%, 7.3%, and 24.2%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect