Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene
| Autor: | Y Koltin, S Knoller, R Ben-Yaacov, Guy A. Caldwell, J M Becker |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Antifungal Agents
Molecular Sequence Data Microbial Sensitivity Tests Saccharomyces cerevisiae Cycloheximide Biology Microbiology chemistry.chemical_compound Transformation Genetic Antibiotic resistance Plasmid Candida albicans Pharmacology (medical) Amino Acid Sequence DNA Fungal Gene Pharmacology Base Sequence Benomyl Drug Resistance Microbial biology.organism_classification Corpus albicans Methotrexate Infectious Diseases chemistry Membrane protein Research Article Plasmids |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 38:648-652 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.38.4.648 |
| Popis: | Candida albicans is not inhibited by a number of drugs known to affect fungal cells. The basis for this resistance in most cases is unknown but has been attributed to the general impermeability of the fungal cell envelope. A gene (BENr) formerly shown to be responsible for the resistance of C. albicans to benomyl and methotrexate was shown in the present study to confer resistance to four other inhibitory compounds: cycloheximide, benztriazoles, 4-nitroquinoline-N-oxide, and sulfometuron methyl. Analysis of the protein database revealed an apparent similarity of the C. albicans gene to membrane protein genes encoding antibiotic resistance in prokaryotes and eukaryotes and a high degree of identity to a recently cloned gene encoding cycloheximide resistance in Candida maltosa. We propose that BENr encodes a protein that operates in a fashion similar, but not identical, to that described for other multiple-drug resistance proteins. |
| Databáze: | OpenAIRE |
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