Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes
| Autor: | Wei-Che Lin, Meng Hsiang Chen, Wen-Chan Chiu, Nai-Wen Tsai, Ben-Chung Cheng, Jung-Fu Chen, Yun-Ru Lai, Cheng-Hsien Lu, Chih-Cheng Huang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Leptin
medicine.medical_specialty Mediation (statistics) Waist Cardiovascular autonomic neuropathy lcsh:Medicine 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology Body Mass Index Prediabetic State 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus medicine Humans Prediabetes Cardiac autonomic reflex tests Longitudinal Studies Composite autonomic scoring scale business.industry Research lcsh:R fungi Type 2 Diabetes Mellitus food and beverages Type 2 diabetes and prediabetes General Medicine medicine.disease Obesity Endocrinology Diabetes Mellitus Type 2 Central obesity Obesity Abdominal Waist circumference business |
| Zdroj: | Journal of Translational Medicine Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020) |
| ISSN: | 1479-5876 |
| Popis: | Background Evidences support the view that central obesity is an independently cardiovascular risk. It is thought that leptin contributes to autonomic dysfunction and cardiovascular risks in type 1 and type 2 diabetes mellitus (T1DM and T2DM). This raises the possibility that leptin might mediate the relationship between central obesity and the severity of cardiovascular autonomic neuropathy (CAN) in patients with well-controlled T2DM and prediabetes. Methods The complete cardiovascular reflex tests and biomarkers were assessed for each patient. The severity of CAN was assessed using composite autonomic scoring scale (CASS). A single-level three-variable mediation model was used to investigate the possible relationships among central obesity [as indicated by waist circumference (WC)], leptin level, and severity of CAN (as indicated by CASS value). Results A total of 107 patients were included in this study: 90 with diabetes and 17 with prediabetes. The results demonstrate that increased WC is associated with increased severity of CAN (r = 0.242, P = 0.017). We further discovered that leptin level is positively correlated with WC (r = 0.504, P Conclusions Our results highlighted the relationship among leptin, central obesity, and severity of CAN. As the leptin level serves as mediator between central obesity and severity of CAN, a longitudinal study is needed to confirm that control of WC can decrease leptin levels and can be effective in reducing CAN progression. |
| Databáze: | OpenAIRE |
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