Assessment of Hydroxyethyl Starch (6% HES 130/0.4) Kidney Storage in Critically Ill Dogs: A Post-mortem Prospective Study
| Autor: | Adamik, Katja-Nicole, Stoffel, Michael H, Tangermann, Simone, de Breuyn Dietler, Bettina, Stokar-Regenscheit, Nadine |
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| Rok vydání: | 2022 |
| Předmět: |
630 Agriculture
tetrastarch General Veterinary Veterinary medicine 610 Medicine & health osmotic nephrosis 500 Science fluid therapy AKI synthetic colloids SF600-1100 570 Life sciences biology 590 Animals (Zoology) Veterinary Science biological phenomena cell phenomena and immunity reproductive and urinary physiology Original Research |
| Zdroj: | Frontiers in Veterinary Science Adamik, Katja-Nicole; Stoffel, Michael H; Tangermann, Simone; de Breuyn Dietler, Bettina; Stokar-Regenscheit, Nadine (2022). Assessment of Hydroxyethyl Starch (6% HES 130/0.4) Kidney Storage in Critically Ill Dogs: A Post-mortem Prospective Study. Frontiers in veterinary science, 8(802507), p. 802507. Frontiers Media 10.3389/fvets.2021.802507 Frontiers in Veterinary Science, Vol 8 (2022) |
| ISSN: | 2297-1769 |
| Popis: | Objective: Intravenous hydroxyethyl starch (HES) solutions are potentially nephrotoxic due to rapid renal tissue uptake, subsequent osmotic nephrosis, and long-lasting intracellular storage. This study aimed to investigate the severity of intracellular storage of HES in renal tissue samples from critically ill dogs receiving 6% HES 130/0.4.Materials and Methods: Fresh, post-mortem (Results: Histology revealed that 2/20 dogs (10%) had no, 11/20 dogs (55%) had mild, 5/20 dogs (25%) had moderate, and 2/20 dogs (10%) had severe VAC. Immunohistochemistry revealed that 5/20 dogs (25%) had no, 6/20 dogs (30%) had mild, 7/20 dogs (35%) had moderate, and 2/20 dogs (10%) had severe ACC. Both changes were predominantly found in the distal tubular epithelium of mild and moderate cases, and all tubular segments were affected in severe cases. Seven of 20 dogs (35%) had osmotic nephrosis (ON). On electron microscopy, large granules with an electron-dense content were repeatedly detected in individual cells, mainly in the distal tubules. No correlation was found between cumulative HES dose or duration of HES administration and VAC grade, ACC grade, or presence/absence of ON.Conclusion: A high percentage of dogs had renal tubular HES storage and one-third of dogs showed HES-induced ON. Short-term HES administration caused VAC and ACC, regardless of the dose or duration of administration. In contrast to previous studies, HES 130/0.4 deposits were mainly located in the renal distal tubule. |
| Databáze: | OpenAIRE |
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