Vasoactive intestinal polypeptide and the female genital tract: relationship to reproductive phase and delivery
| Autor: | Bent Ottesen, Gorm Wagner, Jan Fahrenkrug, Helle Ulrichsen, L. Schierup, J.-J. Larsen, F. Sondergaard |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
medicine.medical_specialty Aging Adolescent media_common.quotation_subject Placenta Sexual Behavior Vasoactive intestinal peptide Umbilical cord Gastrointestinal Hormones Uterine Contraction Pregnancy Internal medicine Medicine Sexual stimulation Humans Child reproductive and urinary physiology Menstrual cycle media_common Aged Labor Obstetric business.industry Reproduction Uterus Myometrium Obstetrics and Gynecology Infant Venous Plasma Venous blood Middle Aged medicine.disease Circadian Rhythm Menstruation medicine.anatomical_structure Endocrinology Child Preschool Female business hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide |
| Zdroj: | American journal of obstetrics and gynecology. 143(4) |
| ISSN: | 0002-9378 |
| Popis: | Recently, vasoactive intestinal polypeptide (VIP) has been localized in nerve fibers in the human female genital tract. In the present investigation, the effect and concentration of VIP was studied in uterine tissue from pregnant and nonpregnant women, and the plasma concentration of VIP was measured in relationship to diurnal rhythm, intake of food, menstrual cycle, pregnancy, labor, age, and sexual arousal. In vitro VIP inhibited the contractions of the nonpregnant but not of the pregnant uterus. The median concentration of VIP in myometrium from pregnant women (less than 0.1 pmole/gm) was significantly lower than that in myometrium from nonpregnant women (1.6 pmoles/gm). The venous plasma concentrations of VIP during labor (10.5 to 13.0 pmoles/L) were significantly higher than those during pregnancy (2.0 to 5.0 pmoles/L) and the menstrual cycle of VIP increased significantly during sexual arousal, from 4.0 to 8.5 pmoles/L. The median arterial and venous concentrations in the umbilical cord (12.5 and 14.5 pmoles/L, respectively) were significantly higher than the concentration in maternal peripheral venous blood (5.2 pmoles/L). The plasma concentrations of VIP were not related to intake of food, diurnal rhythm, menstrual cycle, or age. The conclusion is that the function of VIP may be related to pregnancy, delivery, and sexual stimulation. |
| Databáze: | OpenAIRE |
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