Risk estimation of second primary cancers after breast radiotherapy
| Autor: | Alexandre M. Caraça Santos, Eva Bezak, Loredana G. Marcu, Chia M Wong |
|---|---|
| Přispěvatelé: | Santos, Alexandre MC, Marcu, Loredana G, Wong, Chia M, Bezak, Eva |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Organs at Risk medicine.medical_specialty Lung Neoplasms Brachytherapy Breast Neoplasms medicine.disease_cause secondary carcinogenesis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Esophagus Risk Factors Internal medicine medicine cancer Humans breast radiotherapy Radiology Nuclear Medicine and imaging skin and connective tissue diseases Radiation treatment planning Lung Aged business.industry Stomach Radiotherapy Planning Computer-Assisted Pharynx Partial Breast Irradiation Neoplasms Second Primary Radiotherapy Dosage Hematology General Medicine Middle Aged medicine.disease medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Female business Carcinogenesis |
| Zdroj: | Acta oncologica (Stockholm, Sweden). 55(11) |
| ISSN: | 1651-226X |
| Popis: | Aims: There is evidence towards the induction of second primary cancers (SPCs) after breast radiotherapy (RT). Organs, such as the lungs and the esophagus, have been identified as common sites for SPC formation. As a result, the current study investigated the risk of secondary carcinogenesis associated with particular RT techniques for breast cancer; including whole breast, segmented breast, partial breast and mammosite brachytherapy. Methods: In this study, seven breast cancer patients had all major organs contoured on their planning computed tomography (CT) images. Whole breast, segmented breast, accelerated partial breast irradiation (APBI) and mammosite boost treatment plans were generated for each patient using Pinnacle3 treatment planning system. Differential dose-volume histograms were generated for a number of critical structures: bladder, brain and central nervous system (CNS), breast, colon, liver, lung, mouth and pharynx, esophagus, ovary, salivary gland, small intestine, stomach, and uterus. The lifetime attributed risk (LAR) of cancer induction was estimated using the Schneider et al. excess absolute risk models and dose-volume histograms for the above organs. Results: The sites with the highest LAR estimates were the ipsilateral and contralateral lungs, and contralateral breast for all treatment techniques. For all sites, the LAR estimates for the segmented breast and mammosite treatments were lower than those for the whole breast and APBI treatments. For right-sided target volumes the liver also resulted in high LAR estimates, with all techniques having a LAR greater than 20 per 10 000 person-years (PY), except for mammosite with a mean LAR estimate of 13.2 per 10 000 PY. For left-sided target volumes the stomach also resulted in high LAR estimates, with both whole breast and APBI having a LAR greater than 20 per 10 000 PY, and mammosite the lowest with a LAR of 8.3 per 10 000 PY. Conclusion: It is concluded that the lungs and contralateral breast showed high LAR estimates. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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