Systemic inflammation in the pathogenesis of irritable bowel syndrome associated with obesity
| Autor: | Hanna Yaroslavivna Stupnytska, Michael Ivanovich Sheremet, Yuliya Vyacheslavivna Bilooka, Vyacheslav Vasilievich Bilookyi, Oleksandr V. Bilookyi, Pharmacy, Bucharest, Romania, Yurii Yevgenovych Rogovyi, O.I. Fediv, Valentin Nicolae Varlas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Modern medicine
medicine.medical_specialty obesity CP – ceruloplasmin Fibrinogen Systemic inflammation Gastroenterology Blood serum Internal medicine medicine oxidative stress Humans IL-10 – interleukin-10 Irritable bowel syndrome irritable bowel syndrome Inflammation CRP – C-reactive protein TFNα – tumor necrosis factor-α biology TGFβ1 – transforming growth factor-β1 business.industry Tumor Necrosis Factor-alpha IBS – irritable bowel syndrome General Medicine medicine.disease cytokines Diarrhea Limulus amebocyte lysate IP – 8-isoprostane biology.protein Original Article medicine.symptom business Ceruloplasmin medicine.drug endotoxicosis |
| Zdroj: | Journal of Medicine and Life |
| ISSN: | 1844-3117 1844-122X |
| Popis: | Investigation of the mechanisms promoting the development of irritable bowel syndrome (IBS) in obese patients is one of the most important issues of modern medicine. We examined 97 patients suffering from IBS. The group of comparison included 10 individuals with obesity. The control group included 21 practically healthy individuals. The levels of C-reactive protein (CRP) in the blood serum, tumor necrosis factor-α (TFNα), transforming growth factor-β1 (TGFβ1), interleukin-10 (IL-10), 8-isoprostane (IP), ceruloplasmin (CP) were examined. Endotoxicosis intensity was identified by the content of average molecular peptides in the blood and the Limulus Amebocyte Lysate (LAL) test. In the case of IBS with prevailing diarrhea, especially its comorbid course with obesity, cytokine imbalance was observed, which was manifested by a decreased amount of IL-10 in the blood serum and increased levels of TNFα and TGFβ1. Patients suffering from irritable bowel syndrome with prevailing diarrhea associated with obesity were characterized by high levels of C-reactive protein, fibrinogen and average molecules, increased content of pro-inflammatory cytokines (TFNα and TGFβ1) with a decreased content of IL-10, as well as imbalance of the pro-oxidant and anti-oxidant blood systems (increased content of 8-isoprostane and ceruloplasmin). |
| Databáze: | OpenAIRE |
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