Reversibility of renal cortical lesions induced in rats by high doses of nitrilotriacetate in chronic feeding studies
| Autor: | C. L. Alden, R. L. Kanerva |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Nitrilotriacetic Acid medicine.medical_specialty Pathology Kidney Cortex Time Factors Renal cortex Acetates Toxicology Pathogenesis Internal medicine medicine High doses Animals Dose-Response Relationship Drug Chemistry General Medicine Hyperplasia medicine.disease Kidney Neoplasms Rats Inbred F344 Tumor formation Diet Rats Discontinuation medicine.anatomical_structure Endocrinology Tumour development Toxic injury Food Science |
| Zdroj: | Food and Chemical Toxicology. 20:935-937 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/s0015-6264(82)80231-9 |
| Popis: | The effects in the renal cortex of the male rat of continuous administration of a high dose of nitrilotriacetate (NTA) for 24 months were compared with those of the administration of a similar dose for 18 months followed by a 6-month recovery period on the control diet. The results suggest that discontinuation of treatment interrupts the sequence of events leading to tumour formation. This study indicates that all stages in the proposed pathogenesis of renal tubular tumour formation by NTA, up to the occurrence of adenomalous hyperplasia and neoplasia, are reversible. Apparently, tumour development is dependent on the continuous administration of high doses of NTA in the presence of toxic injury to the majority of nephrons. |
| Databáze: | OpenAIRE |
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