Longitudinal study on the effect of surgical weight loss on beat-to-beat blood pressure variability in patients undergoing bariatric surgery: a study protocol
| Autor: | Nour-Mounira Z. Bakkar, Ramzi S. Alami, Kamal F. Badr, Souha Fares, Issam Lakkis |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Longitudinal study hypertension protocols & guidelines Bariatric Surgery Blood Pressure Cardiovascular Medicine Prehypertension Weight loss Weight Loss medicine Humans Longitudinal Studies business.industry General Medicine Blood flow Institutional review board medicine.disease Obesity Obesity Morbid clinical physiology Surgery Blood pressure Medicine medicine.symptom business Body mass index |
| Zdroj: | BMJ Open, Vol 11, Iss 10 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2021-050957 |
| Popis: | IntroductionAlterations in linear and non-linear parameters of beat-to-beat blood pressure variability (BPV) have been shown to predict disease prognosis and distinguish between risk categories in various pathological conditions, independently of average blood pressure levels. Obesity places subjects at elevated risk of vascular diseases, including hypertension, resulting in serious cardiac, respiratory and cerebral events. However, little is known about the status of vascular dynamics in obese and morbidly obese adults.Methods and analysisIn this present quasi-experimental longitudinal study, changes in beat-to-beat BPV, using continuous, non-invasive blood pressure monitoring, in obese subjects undergoing bariatric surgery are characterised. The capacity of linear and non-linear measures of BPV to detect differences between hypertensive, prehypertensive and normotensive obese subjects prebariatric and postbariatric surgery are tested. Additionally, potential correlations between beat-to-beat BPV and age, body mass index, gender and comorbidities will be investigated. In parallel, the impact of the unsteady fluctuations of beat-to-beat blood pressure on the dynamic stresses imparted by blood flow on blood vessel walls will be explored. We expect to find altered BPV profiles in hypertensive and prehypertensive subjects as compared with normotensive subjects. We also expect to see differential normalisation in BPV profiles between hypertensive, prehypertensive and normotensive subjects over time.Ethics and disseminationThe study has been approved by the Institutional Review Board at the American University of Beirut (IRB ID: BIO-2018-0040). Study results will be made available to the public through publications in peer-reviewed journals and conference papers and/or presentations. |
| Databáze: | OpenAIRE |
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