Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility
| Autor: | L. J. Chandler, Kathleen G. Bryant, Jacqueline M. Barker, Jennifer I. Osborne |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
sex differences
0301 basic medicine Drug taking Rat model Physiology Age and sex Toxicology 03 medical and health sciences 0302 clinical medicine High doses Medicine Pharmacology (medical) habit Original Research Pharmacology behavioral flexibility ethanol exposure business.industry lcsh:RM1-950 Flexibility (personality) Ethanol exposure Cognition lcsh:Therapeutics. Pharmacology 030104 developmental biology rat models adolescence Animal studies business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 8 (2017) |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2017.00450 |
| Popis: | Human alcoholics have been shown to have impaired cognitive control over actions and increased reliance on habitual response strategies. While it is unclear in humans whether these differences predate ethanol exposure or result from chronic drinking, data from animal studies suggest that ethanol acts to promote the development of inflexible behaviors. Here, we investigated how intermittent exposure to high doses of ethanol impacts the ability to flexibly regulate behavior in a habit model. As adolescence, may represent a period of increased drug taking and developmental vulnerability that may impact adult behavior, we compared the effects of high-dose ethanol exposure during adolescence to exposure during adulthood in male and female rats. Our findings indicated that the effects of intermittent, high-dose ethanol exposure on habitual behavior is mediated by age and sex such that ethanol exposure during adolescence promoted the use of habitual response strategies in adult females, but not males, and that the opposite pattern emerged following intermittent, high-dose ethanol exposure in adult rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|