Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan

Autor: Sadanori Okada, Takehiro Sugiyama, Tomoaki Imamura, Tomoya Myojin, Hitoshi Ishii, Tsuneyuki Higashino, Tatsuya Noda, Shinichiro Kubo, Hiroki Nakajima, Yuichi Nishioka
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
Endocrinology
Diabetes and Metabolism
Population
030209 endocrinology & metabolism
Rate ratio
Diseases of the endocrine glands. Clinical endocrinology
Young Adult
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Japan
Diabetes mellitus type 1
Internal medicine
Diabetes mellitus
Influenza
Human
Internal Medicine
medicine
Humans
Poisson regression
Child
education
Aged
Retrospective Studies
Type 1 diabetes
education.field_of_study
business.industry
Incidence
Infant
Retrospective cohort study
Original Articles
General Medicine
Middle Aged
medicine.disease
RC648-665
Confidence interval
Influenza
Diabetes Mellitus
Type 1
030104 developmental biology
Child
Preschool
Cohort
symbols
Female
Original Article
business
Zdroj: Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1797-1804 (2021)
Journal of Diabetes Investigation
ISSN: 2040-1116
2040-1124
Popis: Aim This study aimed to determine whether there is an association between influenza and new‐onset type 1 diabetes. Materials and methods This population‐based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check‐ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new‐onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding. Results The data of 10,400 patients with new‐onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3‐fold (95% confidence interval: 1.15–1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times. Conclusions In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes increased after being diagnosed with influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
Databáze: OpenAIRE
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