The Role of Ghrelin and Ghrelin Signaling in Aging

Autor: Natasya Trivena Rokot, Marie Amitani, Akihiro Asakawa, Yasuhito Nerome, Ippei Shimoshikiryo, Tetsuhiro Owaki, Kimiko Mizuma, Timothy Sean Kairupan, Kai-Chun Cheng, Akio Inui, Haruka Amitani, Nanami Sameshima
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_specialty
Aging
ghrelin resistance
media_common.quotation_subject
Calorie restriction
Aging society
Review
Biology
Catalysis
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
longevity
Internal medicine
Orexigenic
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
media_common
Caloric Restriction
ghrelin agonist
Mechanism (biology)
Organic Chemistry
digestive
oral
and skin physiology
Longevity
General Medicine
calorie restriction
Computer Science Applications
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
ghrelin
Ghrelin
Signal transduction
030217 neurology & neurosurgery
hormones
hormone substitutes
and hormone antagonists
Hormone
medicine.drug
Signal Transduction
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1511 (2017)
ISSN: 1422-0067
Popis: With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism.
Databáze: OpenAIRE
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