Silver microparticles plus fibrin tissue sealant prevents incisional hernias in rats
| Autor: | Frank Primus, David M. Young, Hobart W. Harris, James P. Grenert |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Silver Incisional hernia medicine.medical_treatment Fibrin Tissue Adhesive 030230 surgery Fibrin Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Tensile Strength medicine Animals Humans Incisional Hernia Hernia Saline Abdominal Muscles Wound Healing biology business.industry Incidence Sealant Abdominal Wall Tissue sealant medicine.disease Fibrosis Hernia Abdominal Rats Surgery Disease Models Animal Treatment Outcome surgical procedures operative 030220 oncology & carcinogenesis biology.protein Tissue Adhesives Wound healing business Abdominal surgery |
| Zdroj: | Journal of Surgical Research. 227:130-136 |
| ISSN: | 0022-4804 |
| Popis: | Open abdominal surgery is frequently complicated by the subsequent development of an incisional hernia. Consequently, more than 400,000 incisional hernia repairs are performed each year, adding over $15 billion per year to U.S. health-care expenditures. While the vast majority of studies have focused on improved surgical techniques or prosthetic materials, we examined the use of metallic silver microparticles to prevent incisional hernia formation through enhanced wound healing.A rodent incisional hernia model was used. Eighty-two rats were randomly placed into two control groups (saline alone and silver microparticles alone), and three experimental groups (0 mg/cm, 2.5 mg/cm, and 25 mg/cm of silver microparticles applied with a fibrin sealant). Incisional hernia incidence and size, tensile strength, and tissue histology were assessed after 28 days.A significant reduction of both incisional hernia incidence and hernia size was observed between the control groups and 2.5 mg/cm group, and between the control and 25 mg/cm group by nearly 60% and 90%, respectively (P 0.05). Histological samples showed a noticeable increase in new fibrosis in the treated animals as compared with the controls, whereas the tensile strength between the groups did not differ.The novel approach of using silver microparticles to enhance wound healing appears to be a safe and effective method to prevent incisional hernias from developing and could herald a new era of medicinal silver use. |
| Databáze: | OpenAIRE |
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