Sequential Analysis of Trace Elements in a Micro Volume Urine Sample Using Inductively Coupled Plasma Mass Spectrometry
| Autor: | Ralf Kinscherf, Nico Laur, Hans-Peter Deigner, Lars Kaiser |
|---|---|
| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
QH301-705.5 QC1-999 micro volume trace elements inductively coupled plasma mass spectrometry (ICP-MS) 010501 environmental sciences 01 natural sciences 03 medical and health sciences General Materials Science Biology (General) Instrumentation Inductively coupled plasma mass spectrometry QD1-999 030304 developmental biology 0105 earth and related environmental sciences Fluid Flow and Transfer Processes validation 0303 health sciences Chromatography Chemistry Process Chemistry and Technology Physics General Engineering Engineering (General). Civil engineering (General) Computer Science Applications Trace (semiology) Volume (thermodynamics) TA1-2040 Urine sample |
| Zdroj: | Applied Sciences, Vol 11, Iss 3740, p 3740 (2021) Applied Sciences Volume 11 Issue 9 |
| ISSN: | 2076-3417 |
| Popis: | In this work, we describe a simple, fast, cheap, accurate and high-throughput method for the determination of Al V Cr Mn Fe Co Cu Zn As Se Mo Cd Sn Ba TI Pb in a micro volume of urine by using inductively coupled mass spectrometry (ICP-MS) equipped with an octupole-based collision cell. The samples were directly analyzed after a simple acidification with 3% nitric acid. Validation of this method was performed by using certified urine reference material. He and H were used as collision gas for reducing polyatomic interference for most of the measured elements. Finally, we partook in an external quality assurance conducted by ISNTAND e.V. 2. Results show that our high-throughput method is ideal for detecting elements in newborns and infants because of its simplicity, speed, accuracy and low sample volume. |
| Databáze: | OpenAIRE |
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