Trace Elements in Children with Acute Lymphoblastic Leukemia
| Autor: | Mohammadreza Bordbar, Haleh Bozorgi, Mehran Karimi, Fereshteh Majidi, Shirin Parand, Omid Reza Zekavat, Sezaneh Haghpanah |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Cohort Studies 03 medical and health sciences 0302 clinical medicine Quality of life Acute lymphocytic leukemia Internal medicine medicine Humans Child Chemotherapy business.industry Confounding Induction chemotherapy Combination chemotherapy General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Prognosis medicine.disease Trace Elements Regimen 030104 developmental biology 030220 oncology & carcinogenesis Female business Follow-Up Studies Cohort study |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 22:43-47 |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2021.22.s1.43 |
| Popis: | Objective: Although combined chemotherapy regimen leads to 80% remission in children with acute lymphocytic leukemia (ALL), malnutrition and altered serum trace elements as a consequence of chemotherapy agents, have become the new issue to deal with. With the aim to evaluate each trace element in childhood ALL, we investiguâtes six main trace elements before and after induction chemotherapy while considering age, gender and chemotherapy protocol as confounding factors. Methods: Thirty-six newly diagnosed ALL children were recruited, and trace elements were assessed by atomic absorption spectrometry technique. Trace elements (Zinc, Copper, Manganese, Magnesium, Chromium and Iron) decreased significantly after induction chemotherapy. Results: Considering the confounding factors, mean difference of elements decreased significantly, except for Chromium. Its mean difference was only significant in children younger than 10 and those who had received standard risk chemotherapy. Conclusion: In conclusion, all the studied trace elements decreased significantly after induction chemotherapy session in ALL children. This highlights the importance of complementary and supplementary management. A larger cohort study with longer follow up is warranted to elucidate the long-term effect of chemotherapy on these trace elements on the general health status, quality of life or risk of relapse in ALL children. |
| Databáze: | OpenAIRE |
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