Melanin Biosynthesis Inhibitors from TarragonArtemisia dracunculus
| Autor: | Osamu Ohno, Kohji Yamaguchi, Nobuo Uotsu, Norihito Maru, Taeko Watabe, Masayoshi Yamada, Tomohiro Chiba, Masaru Kawagoshi, Kazuhiko Nakamura, Daisuke Uemura |
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| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Skin Neoplasms Cell Survival Polyunsaturated Alkamides Melanoma Experimental Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Melanin Inhibitory Concentration 50 Mice Melanin biosynthesis Tumor Cells Cultured Animals Humans Molecular Biology Melanins biology Plant Extracts Family Asteraceae Organic Chemistry Skin whitening General Medicine Dracunculus (plant) Mouse Melanoma biology.organism_classification Artemisia alpha-MSH Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 75:1628-1630 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | The EtOH extract of tarragon Artemisia dracunculus, a perennial herb in the family Asteraceae, was found to potently inhibit α-melanocyte-stimulating hormone (α-MSH) induced melanin production in B16 mouse melanoma cells. Bioassay-guided fractionation led to the isolation of two alkamide compounds, isobutyl (1) and piperidiyl (2) amides of undeca-2E,4E-dien-8,10-dynoic acid. The respective EC(50) values for melanin biosynthesis inhibition were 1.8 and 2.3 µg/mL for 1 and 2. |
| Databáze: | OpenAIRE |
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