HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE
| Autor: | Sônia Pereira Leite, Maria Bernadete de Sousa Maia, Tainá Maria Santos da Silva, Ivanise Brito da Silva, Izabela Rangel Lima, Roberta M Leite Lima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Antioxidant Bilirubin medicine.medical_treatment 0211 other engineering and technologies 02 engineering and technology RC799-869 Pharmacology Protective Agents Antioxidants 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Biological property 021105 building & construction Chemical and drug induced liver injury medicine Animals Liver damage Aspartate Aminotransferases Organ regeneration Acetaminophen Liver injury biology business.industry Plant Extracts Gastroenterology Alanine Transaminase Analgesics Non-Narcotic Diseases of the digestive system. Gastroenterology medicine.disease biology.organism_classification Indigofera chemistry 030220 oncology & carcinogenesis Indigofera suffruticosa Indigofera drug effects business medicine.drug |
| Zdroj: | Arquivos de Gastroenterologia, Vol 56, Iss 4, Pp 333-338 (2019) |
| ISSN: | 1678-4219 |
| Popis: | BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes. Several biological properties, such as anti-inflammatory, anticancer, antitumor, hepatoprotective and low toxicity, are reported for this plant. OBJECTIVE: This study investigated hepatoprotective activity and the antioxidant effect of methanolic extract of I. suffruticosa leaves (MEIS) on Swiss albino mice submitted to experimental models of acetaminophen-induced liver injury. METHODS: MEIS (50 mg/kg; p.o.) was standardized according to the LD50 and its hepatoprotective property on Swiss albino mice evaluated during a 7-day period. On the eighth day, the acetaminophen-induced hepatic injury was performed. Histomorphometric analysis of liver tissue, antioxidant activity and serum levels of alanine aminotransferase (AST), aspartate aminotransferase (ALT) and bilirubin were measured. RESULTS: MEIS (50 mg/kg; p.o.) restored serum enzyme levels and results were close to those of positive control (silymarin) when compared to the negative control. Histopathological and histomorphometric analyzes confirmed MEIS hepatoprotective activity, showing reorganization of structural units of cells, nuclei and sinusoidal capillaries of hepatocytes, reducing the damage on liver tissue and increasing organ regeneration rate. MEIS showed high antioxidant potential at concentrations of 1000 and 500 µg/mL. CONCLUSION: This study suggests that MEIS has hepatoprotective activity and high antioxidant potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|